Publications by authors named "S J Staal"

The implementation of nature-based interventions has demonstrated a positive impact on health outcomes and overall wellbeing. The knowledge of nature-based smoking cessation interventions is sparse but might offer potential benefits for smokers undertaking an intensive smoking cessation program. This study assessed the feasibility in real life of the 6-week Danish Intensive Gold Standard Program (GSP) for smoking cessation in nature compared to the standard setting in primary healthcare.

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Objective: We aimed to evaluate the diagnostic accuracy of heparin-binding protein (HBP) in cerebrospinal fluid for the diagnosis of bacterial meningitis in patients with a suspected central nervous system infection.

Methods: This prospective multicenter cohort study determined the diagnostic accuracy of HBP in cerebrospinal fluid (CSF) for bacterial meningitis among a cohort of consecutive patients with a suspected central nervous infection. The final clinical diagnosis was considered the reference standard.

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Aim: The four-item questionnaire test (4QT) is a simple screening measure of dysphagia for older people. A positive answer to any item indicates the need for further assessment. The 4QT is fast, simple to apply and requires no training beforehand.

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Article Synopsis
  • BAP1 mutations lead to a loss of function affecting cell cycle and DNA repair, making patients potentially responsive to PARP inhibitors like niraparib.
  • A phase II trial evaluated niraparib in patients with advanced tumors likely to have mBAP1 mutations, focusing on response rates, progression-free survival, and overall survival.
  • Despite not meeting the primary efficacy goal, some clinical benefits were observed in patients with confirmed mBAP1 mutations, suggesting the need for further research.
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