Clinical modeling of motor function to predict treatment efficacy and enable in silico treatment comparisons in infantile-onset Pompe disease.

Infantile-onset Pompe disease (IOPD) is a rare, deadly, quickly-progressing degenerative disease. Even with life-sustaining treatment (e.g.

The Magnitude of the Blood Acid-Base Response, but Not Time to Peak, Is Reliable Following the Ingestion of Acute, Individualized Sodium Citrate.

Enhanced buffering capacity following sodium citrate (SC) ingestion may be optimized when subsequent exercise commences at individual time-to-peak (TTP) alkalosis (blood pH or bicarbonate concentration [HCO3-]). While accounting for considerable interindividual variation in TTP (188-300 min), a reliable blood alkalotic response is required for practical use. This study evaluated the reliability of blood pH, HCO3-, and sodium (Na+) following acute SC ingestion.

Heat resistance differences are common between both vegetative cells and spores of type F isolates carrying a chromosomal vs plasmid-borne enterotoxin gene.

type F isolates utilize enterotoxin (CPE) to cause food poisoning (FP) and nonfoodborne gastrointestinal diseases. The enterotoxin gene () can be located on either the chromosome or plasmids, but most FP isolates carry a chromosomal (c) gene. Our 2000 article in (66:3234-3240, 2000, https://doi.

Characterising cerebrovascular reactivity and the pupillary light response-a comparative study.

Introduction: Smooth muscle is integral to multiple autonomic systems, including cerebrovascular dynamics through vascular smooth muscle cells and in ocular muscle dynamics, by regulating pupil size. In the brain, smooth muscle function plays a role in cerebrovascular reactivity (CVR) that describes changes in blood vessel calibre in response to vasoactive stimuli. Similarly, pupil size regulation can be measured using the pupillary light response (PLR), the pupil's reaction to changes in light levels.