Application of high-density 2D receiver coil arrays for improved SNR in prostate MRI.

Purpose: To study if adaptive image receive (AIR) receiver coil elements can be configured into a 2D array with high (>45% by diameter) element-to-element overlap, allowing improved SNR at depth (0.7-1.5× element diameter) versus conventional (20%) overlap.

A new MVA ancestor-derived oncolytic vaccinia virus induces immunogenic tumor cell death and robust antitumor immune responses.

Vaccinia viruses (VACVs) are versatile therapeutic agents and different features of various VACV strains allow for a broad range of therapeutic applications. Modified VACV Ankara (MVA) is a particularly altered VACV strain that is highly immunogenic, incapable of replicating in mammalian hosts, and broadly used as a safe vector for vaccination. Alternatively, Western Reserve (WR) or Copenhagen (Cop) are VACV strains that efficiently replicate in cancer cells and, therefore, are used to develop oncolytic viruses.

Comparison of model-based versus deep learning-based image reconstruction for thin-slice T2-weighted spin-echo prostate MRI.

Purpose: To compare a previous model-based image reconstruction (MBIR) with a newly developed deep learning (DL)-based image reconstruction for providing improved signal-to-noise ratio (SNR) in high through-plane resolution (1 mm) T2-weighted spin-echo (T2SE) prostate MRI.

Methods: Large-area contrast and high-contrast spatial resolution of the reconstruction methods were assessed quantitatively in experimental phantom studies. The methods were next evaluated radiologically in 17 subjects at 3.

Improving poxvirus-mediated antitumor immune responses by deleting viral cGAMP-specific nuclease.

cGAMP-specific nucleases (poxins) are a recently described family of proteins dedicated to obstructing cyclic GMP-AMP synthase signaling (cGAS), an important sensor triggered by cytoplasmic viral replication that activates type I interferon (IFN) production. The B2R gene of vaccinia viruses (VACV) codes for one of these nucleases. Here, we evaluated the effects of inactivating the VACV B2 nuclease in the context of an oncolytic VACV.

Model-based image reconstruction with wavelet sparsity regularization for through-plane resolution restoration in T -weighted spin-echo prostate MRI.

Purpose: The purpose is to develop a model-based image-reconstruction method using wavelet sparsity regularization for maintaining restoration of through-plane resolution but with improved retention of SNR versus linear reconstruction using Tikhonov (TK) regularization in high through-plane resolution (1 mm) T -weighted spin-echo (T2SE) images of the prostate.

Methods: A wavelet sparsity (WS)-regularized image reconstruction was developed that takes as input a set of ≈80 overlapped 3-mm-thick slices acquired using a T2SE multislice scan and typically 30 coil elements. After testing in contrast and resolution phantoms and calibration in 6 subjects, the WS reconstruction was evaluated in 16 consecutive prostate T2SE MRI exams.