The effect of prostaglandins A2,E1,E2,15 methyl E2, 16, 16 dimethyl E2 and F2 alpha on erythropoiesis.

Prostaglandins A2, E1, E2, methylated E2s, and F2 alpha affected erythropoiesis and/or erythropoietin (Ep) production. This action is indicated in the exhypoxic, polycythemic mouse where radioiron incorporations into RBC increased after administration of these compounds. The kidney and liver have been indicated through previous studies, to actively participate in Ep production.

Recovery of an erythropoietin inducing factor from the regenerating rat liver.

The perfusion of livers of partially hepatectomized (H mean) rats lends support to earlier findings that the regenerating rat liver is the source of an erythropoietin-inducing hepatic factor (Ep-IHF) which stimulates hepatic production of extrarenal erythropoietin (Ep). Blood plasma was collected from perfused livers of rats that were partially hepatectomized (H mean) 48 to 72 hrs prior to perfusion with whole blood from normal rats. This plasma, when injected into normal rats which were nephrectomized (N mean) and rendered hypoxic 18 hrs after injection, evoked a significant increase in Ep values when compared to blood plasma collected from perfused livers of normal rats.