Two cases of posterior spinal fixation with titanium mesh cage and fenestrated pedicle screw for pyogenic spondylitis.

Pyogenic spondylitis in older patients with osteoporosis presents significant challenges due to implant failure and comorbidities. This study reports two cases of osteoporotic pyogenic spondylitis with substantial bony destruction, treated with cement-augmented pedicle screws (CAPS) and titanium mesh cages (TMC). Both patients achieved complete eradication of infection, spinal stabilization, and favorable clinical outcomes without recurrence or implant failure during follow-up.

Upregulated Nuclear Y-box Binding Protein-1 Expression is Closely Associated with Mammalian Target of Rapamycin Expression in Endometrial Cancer.

Enhanced oncogenic Y-box binding protein-1 (YB-1) expression, associated with the aberrant expression of genes involved in cell proliferation, survival, and drug resistance, can predict prognostic outcomes in patients with various malignancies. We examined whether YB-1 could predict prognostic outcomes in patients with endometrial cancer and whether enhanced YB-1 expression affects the expression of mammalian target of rapamycin (mTOR) in endometrial cancer. We examined the expression levels of YB-1 and mTOR in tumor samples of 166 patients with endometrial cancer, including those with endometrioid grade 1-3, serous carcinoma, and stage I-IV disease, who underwent surgery.

Tegafur-uracil maintenance chemotherapy post-chemoradiotherapy for cervical cancer: Randomized trial.

Aim: Concurrent chemoradiotherapy (CCRT) is the standard treatment for locally advanced cervical cancer (LACC), but recurrence rates remain high. This multicenter phase-3 randomized trial (GOTIC-002) evaluated the efficacy of low-dose oral tegafur-uracil (UFT) as maintenance chemotherapy following curative CCRT for LACC.

Methods: Between 2010 and 2018, 351 patients with stage Ib2-IVa cervical cancer were enrolled.

Robot-Assisted Approach to Diabetes Care Consultations: Enhancing Patient Engagement and Identifying Therapeutic Issues.

: Diabetes is a rapidly increasing global health challenge compounded by a critical shortage of diabetes care and education specialists. Robot-assisted diabetes care offers a cost-effective and scalable alternative to traditional methods such as training and dispatching human experts. This pilot study aimed to evaluate the feasibility of using robots for diabetes care consultations by examining their ability to elicit meaningful patient feedback, identify therapeutic issues, and assess their potential as substitutes for human specialists.

Prevalence and Clinical Characteristics of -Associated Hearing Loss Identified in a Cohort of 7065 Japanese Patients with Hearing Loss.

Background/objectives: Hearing loss is one of the most common sensorineural impairments, and approximately 60% of early-onset cases are due to genetic variations. The otogelin-like protein, encoded by the gene, is a component of the acellular membranes of the inner ear, such as the tectorial membrane, and is thought to play an important role in cochlear amplification. gene variants are a rare cause of hearing loss such as DFNB84B, a mild-to-moderate sensorineural hearing loss presenting in early childhood with autosomal recessive inheritance.