Comparative Evaluation of Different Obturation Techniques for Root Canal Filling of Permanent Teeth: An In-Vitro Study.

Introduction: Achieving success in root canal (RC) therapy relies on three key components: comprehensive cleaning of the canal, efficient disinfection, and proper filling of the canal space. The present study aimed to compare the efficacy of four obturation techniques: single cone (SC), GuttaCore (GC), cold lateral condensation (LC), and C Point system for RC filling of permanent teeth.

Materials And Methods: 76 extracted human mandibular first premolars were divided into four groups, with 19 teeth in each group (group A, obturation with SC technique; group B, obturation with GC; group C, obturation with LC; and group D, obturation with C Point system).

Rest-fMRI-A Potential Substitute for Task-fMRI?

 The aim of this study was to assess the reliability of resting-state functional magnetic resonance imaging (rest-fMRI) in mapping language areas for preoperative planning, versus standard task-based techniques, which are at times difficult to perform in clinical settings. Our study also aimed to evaluate the overlap between language areas identified through rest-fMRI and the standard task-fMRI, in neurosurgical cases.  Using a seed-based analysis of rest-fMRI with multiple template seeds, we identified functionally connected language regions in patients undergoing preoperative language mapping.

Partnering for Better Health: Using Continuous Glucose Monitoring and Clinical Pharmacist Collaboration to Improve Glycemic Control in Underserved Patients With Type 2 Diabetes.

Purpose: The purpose of this study was to examine the effect of initiating use of a continuous glucose monitor (CGM) in patients being treated for type 2 diabetes mellitus, specifically those who face barriers to obtaining this device because of its cost.

Methods: This retrospective medical record review compared diabetes control of patients before and after use of a CGM device within a single primary care office. Patient medical records were reviewed 18 months after initial CGM was provided, and only those who received a CGM directly from the clinic were included in the review.

Synthesis of SGLT2 Inhibitors by Means of Fukuyama Coupling Reaction.

Disclosed herein is a novel and efficient synthesis of dapagliflozin and canagliflozin, the most advanced sodium glucose cotransporter 2 inhibitors (SGLT2 inhibitors), for the treatment of type 2 diabetes mellitus (T2DM). Per Ac-protected thioester was prepared by the treatment of per Ac d-gluconolactone with 1-dodecanethiol and PrMgCl without affecting labile Ac-protecting groups. Aryl bromide (ArBr) was synthesized through reduction of diaryl ketone to diaryl methane by the TiCl/NaBH/DME-MeOH reduction system.

Improvement of LED-based photoacoustic imaging using lag-coherence factor (LCF) beamforming.

Background: Owing to its portability, affordability, and energy-efficiency, LED-based photoacoustic (PA) imaging is increasingly becoming popular when compared to its laser-based alternative, mainly for superficial vascular imaging applications. However, this technique suffers from low SNR and thereby limited imaging depth. As a result, visual image quality of LED-based PA imaging is not optimal, especially in sub-surface vascular imaging applications.