Dual roles of extracellular vesicles in acute lymphoblastic leukemia: implications for disease progression and theranostic strategies.

Acute Lymphoblastic Leukemia (ALL) is a heterogeneous blood cancer characterized by the uncontrolled growth of immature lymphoid cells due to dysregulated signaling pathways. It is the most common pediatric cancer, with high cure rates in children, but significantly lower survival rates in adults. Current theranostic strategies, including chemotherapy, immunotherapy, and nanomedicine, aim to improve detection and treatment precision but are limited by side effects, drug resistance, high costs, and stability issues.

Ethics considerations for precision medicine research and genetic testing in low- and middle-income countries.

Background: Genetic data transfer within multicentre clinical trials conducted in low- and middle-income countries is common and must be communicated to study participants as part of ethical requirements.

Aims: To analyse ethics practices in precision medicine research in low- and middle-income countries and make useful recommendations.

Methods: We conducted a narrative review of published literature and existing ethics frameworks regarding underrepresentation of low- and middle-income countries in genomic databases, informed consent and data security discussions, as well as the potential for exploitation and limited access to benefits.

Enhanced detection of surface deformations in LPBF using deep convolutional neural networks and transfer learning from a porosity model.

Our previous research papers have shown the potential of deep-learning models for real-time detection and control of porosity defects in 3D printing, specifically in the laser powder bed fusion (LPBF) process. Extending these models to identify other defects like surface deformation poses a challenge due to the scarcity of available data. This study introduces the use of Transfer Learning (TL) to train models on limited data for high accuracy in detecting surface deformations, marking the first attempt to apply a model trained on one defect type to another.

A High Likelihood of a Disastrous Outcome: A Case Report of a Complication From the Cosmetic Use of Hyaluronic Acid.

Hyaluronic acid (HA) injections are a generally safe procedure, primarily performed to achieve a more aesthetically appealing appearance. Despite the safety of HA filler procedures, complications may arise in some individuals, such as tenderness, lumpiness, swelling, bruising, neurological impairments, embolism, soft-tissue necrosis, irreversible scarring, and baldness. We present a case of a 36-year-old previously healthy female who was injected with HA filler (Juvederm Voluma®) into the nasolabial folds for cosmetic purposes.

Treacherous territory: Temple fillers and tissue necrosis.

Temporal region of the face is considered the most promising facial region for inducing panfacial effects, playing an increasingly important role in facial contouring and rejuvenation surgeries, which in turn has led to a rapid growth in the demand for aesthetic correction for temporal hollowing. In order to correct this issue and achieve a more youthful appearance, filler injections can be used. Although this procedure is generally safe and is increasingly popular, complications may happen.