Publications by authors named "S J McIlwain"
Article Synopsis
- Ultradense peptide binding arrays provide a means to study millions of peptides in serum samples, enhancing our understanding of immune responses through antibody profiling.
- The HERON R package was developed to identify immunogenic epitopes and analyze antibody targets across multiple samples while estimating their significance at different biological levels.
- HERON is competitive in identifying key antibody regions for diagnostics and treatment, and it's available for use on Bioconductor at the provided link.
Article Synopsis
- Estrogen receptor-positive (ER-positive) breast cancer often recurs later after initial treatment, and high levels of the protein GRHL2 are linked to a worse prognosis compared to ER-negative types.
- *GRHL2 boosts traits associated with stem cells and dormancy in ER-positive breast cancer cells, resulting in a stronger epithelial identity and a shift towards a hybrid epithelial to mesenchymal transition (EMT).
- *Research shows that increased GRHL2 leads to reduced cell growth and greater dormancy marker expression, along with enhanced self-renewal capabilities and changes in influential transcription factor motifs, suggesting it plays a significant role in cancer progression.*
Introduction: Before they can produce their own antibodies, newborns are protected from infections by transplacental transfer of maternal IgG antibodies and after birth through breast milk IgA antibodies. Rhinovirus (RV) infections are extremely common in early childhood, and while RV infections often result in only mild upper respiratory illnesses, they can also cause severe lower respiratory illnesses such as bronchiolitis and pneumonia.
Methods: We used high-density peptide arrays to profile infant and maternal antibody reactivity to capsid and full proteome sequences of three human RVs - A16, B52, and C11.
Yin Yang 1 (YY1) and structural maintenance of chromosomes 3 (SMC3) are 2 critical chromatin structural factors that mediate long-distance enhancer-promoter interactions and promote developmentally regulated changes in chromatin architecture in hematopoietic stem/progenitor cells (HSPCs). Although YY1 has critical functions in promoting hematopoietic stem cell (HSC) self-renewal and maintaining HSC quiescence, SMC3 is required for proper myeloid lineage differentiation. However, many questions remain unanswered regarding how YY1 and SMC3 interact with each other and affect hematopoiesis.
View Article and Find Full Text PDFBreast cancer is often treated with chemotherapy. However, the development of chemoresistance results in treatment failure. Long non-coding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) has been shown to contribute to chemoresistance in breast cancer cells.
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