Publications by authors named "S J Ludtke"
Electron cryo-tomography (cryo-ET) is a powerful imaging tool that allows three-dimensional visualization of subcellular architecture. During morphological analysis, reliable tomogram segmentation can only be achieved through high-quality data. However, unlike single-particle analysis or subtomogram averaging, the field lacks a useful quantitative measurement of cellular tomogram quality.
View Article and Find Full Text PDFThe authors wish to update the article title to "Cryo-Electron Tomography of Plasma Membrane Proteins" [...
View Article and Find Full Text PDFArticle Synopsis
- In January 2020, a workshop at EMBL-EBI focused on data needs for cryoEM structure deposition and validation, specifically in single-particle analysis.
- The workshop gathered 47 experts to discuss data processing, model building, validation, and archiving, leading to consensus recommendations.
- The report outlines the workshop's goals, key discussions, challenges for future methods, and the progress made on implementing the recommendations.
Article Synopsis
- PFAS (per- and polyfluoroalkyl substances) are persistent chemicals found in humans, linked to health issues like immune problems and cancer.
- Research shows PFAS bind differently to key blood proteins (HSA and globulins) based on the length of their carbon chains, affecting their transport and toxicity.
- The varying levels of PFAS binding in individuals highlight the importance of these proteins in studying the health impacts of PFAS exposure.
Article Synopsis
- - A workshop at EMBL-EBI in January 2020 brought together 47 experts to discuss data needs for cryoEM structures, focusing particularly on single-particle analysis.
- - The report outlines the workshop's purpose, the discussions held, and the consensus recommendations made by the attendees.
- - It also highlights future challenges in method development and notes the progress made on implementing some of the recommendations discussed.