Publications by authors named "S J Locke"
Osteoporosis is a major risk factor for fragility fractures. The British Orthopaedics Association Standards for Trauma and Orthopaedics (BOAST) and Getting it Right First Time (GIRFT) guidelines on fragility fracture management highlight the need to initiate prompt, coordinated multidisciplinary care with a focus on early mobilisation to improve patient outcomes. Medical management of fragility fractures focuses on the prevention of progressive frailty.
View Article and Find Full Text PDFGemtuzumab ozogamicin (GO) is a CD33-targeting antibody-drug conjugate approved for the treatment of CD33-positive de novo and relapsed and refractory acute myeloid leukemia (AML). Subset analyses have demonstrated improved clinical outcomes in patients with favorable-risk disease. It is unclear whether the addition of GO to cytarabine and anthracycline chemotherapy (7+3) improves clinical outcomes compared with other conventional regimens for AML.
View Article and Find Full Text PDFArticle Synopsis
- - A new species of the Allocreadiidae family was discovered in mugilid fish in western Puerto Rico, increasing the total species count in this genus to seven.
- - This new parasite is characterized by distinct features including size differences and specific morphological traits, alongside genetic divergence of 0.64%-3.45% in a sequenced gene.
- - The study also provides new mitochondrial and nuclear genetic data to support future evolutionary studies, revealing conflicting results in the phylogenetic relationships among species in the Allocreadiidae family.