Publications by authors named "S J Lindstrom"
Integrating genome-wide association study (GWAS) and transcriptomic datasets can help identify potential mediators for germline genetic risk of cancer. However, traditional methods have been largely unsuccessful because of an overreliance on total gene expression. These approaches overlook alternative splicing, which can produce multiple isoforms from the same gene, each with potentially different effects on cancer risk.
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- * Researchers transplanted various MB cells into zebrafish embryos, observing tumor development and using RNA sequencing to analyze changes in gene expression.
- * The study found that zebrafish can show rapid tumor growth and provide insights into drug testing, offering a promising alternative to traditional mouse models for MB research.