The role of physical activity, sedentary behaviour, diet, adiposity and body composition on health-related quality of life and cancer-related fatigue after diagnosis of colorectal cancer: a Global Cancer Update Programme (CUP Global) systematic literature review and meta-analysis.

Background: The impact of physical activity, sedentary behaviour, diet, adiposity, and body composition on health-related quality of life (HRQoL) and cancer-related fatigue among colorectal cancer survivors remains uncertain.

Methods: PubMed, Embase, and CENTRAL were systematically searched until April 2023 for relevant randomised controlled trials (RCTs) and cohort studies. Random-effects meta-analyses or descriptive syntheses were conducted depending on the number of studies.

Comparison of WET UCIO powder suspension and novel luminescent techniques for latent fingermark detection on the adhesive side of tape.

Pressure-sensitive adhesive tapes are a common vector for latent fingermarks in forensic investigations, often detected using powder suspension techniques. Among these, WET UCIO, employed by the Mossos d'Esquadra Central Fingerprint Development Laboratory Scientific Police Division in Catalonia, Spain, is a carbon black powder suspension method showing promise for casework. WET UCIO also utilises a cost-effective detergent solution, enhancing its practicality and sustainability.

Low-level neurostimulation of the renal nerves as a potential therapeutic strategy for hypertension treatment.

Background: Neurostimulation is an emerging treatment for conditions like hypertension. The renal nerves, comprising sensory afferent and sympathetic efferent fibers, are crucial for blood pressure (BP) regulation. The inhibitory reno-renal reflex, where central integration of renal sensory input reduces sympathetic outflow and systemic BP, presents a promising target for neurostimulation interventions.

Could adaptive deep brain stimulation treat freezing of gait in Parkinson's disease?

Next-generation neurostimulators capable of running closed-loop adaptive deep brain stimulation (aDBS) are about to enter the clinical landscape for the treatment of Parkinson's disease. Already promising results using aDBS have been achieved for symptoms such as bradykinesia, rigidity and motor fluctuations. However, the heterogeneity of freezing of gait (FoG) with its wide range of clinical presentations and its exacerbation with cognitive and emotional load make it more difficult to predict and treat.

IVF success rates in individuals accessing preimplantation genetic testing for monogenic conditions (PGT-M): a single centre retrospective cohort study of 572 IVF cycles.

Purpose: To evaluate live birth rates per embryo transfer where the primary indication for assisted reproduction was preimplantation genetic testing for monogenic conditions.

Methods: All oocytes were fertilized using intracytoplasmic sperm injection. On days 5-7, ~ 5 trophectoderm cells were biopsied.