Publications by authors named "S J Leib"
Article Synopsis
- A growing body of research shows that even mild cases of viral meningitis and meningoencephalitis can lead to lasting health issues.
- This study followed 50 patients over 20 months to assess the long-term effects of these conditions on their daily social and professional lives, revealing significant cognitive and fatigue-related problems.
- Despite improvements over time, 67% of patients still experienced persistent symptoms, with about 30% reporting that these issues affected their everyday activities.
The genus, comprising at least 13 species, is associated with the polymicrobial disorder bacterial vaginosis (BV). However, the details of BV pathogenesis are poorly defined, and the contributions made by individual species, including spp., are largely unknown.
View Article and Find Full Text PDFTreatment of pneumococcal infections is limited by antibiotic resistance and exacerbation of disease by bacterial lysis releasing pneumolysin toxin and other inflammatory factors. We identified a previously uncharacterized peptide in the Klebsiella pneumoniae secretome, which enters Streptococcus pneumoniae via its AmiA-AliA/AliB permease. Subsequent downregulation of genes for amino acid biosynthesis and peptide uptake was associated with reduction of pneumococcal growth in defined medium and human cerebrospinal fluid, irregular cell shape, decreased chain length and decreased genetic transformation.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the effects of reducing genomic sequencing on SARS-CoV-2 surveillance outcomes in Switzerland, analyzing over 143,000 sequences.
- Results show that while some key outcomes like variant detection and cluster analysis could still be achieved with only 35% of the original sequencing effort, this reduction varies significantly by viral lineage.
- The research highlights the need for genomic surveillance programs to balance cost and public health benefits, emphasizing that reduced sequencing may compromise accuracy in tracking emerging variants of concern.
Article Synopsis
- * An analysis of 129 cases revealed that the most common causes were tick-borne encephalitis (TBE) and unknown pathogens, with 88% of patients showing lasting symptoms at discharge and 39% still affected after 17 months.
- * The presence of FLAIR lesions and restricted diffusion on initial MRI scans were linked to poorer patient outcomes, suggesting that these MRI features could serve as important prognostic indicators.