Publications by authors named "S J Kittner"
The association of SUR1 polymorphisms with acute infarct size: The MRI-GENIE study.
J Stroke Cerebrovasc Dis
January 2025
Article Synopsis
- The study investigates the role of SUR1, encoded by the ABCC8 gene, in ischemic strokes and its association with cerebral edema and functional outcomes.
- Researchers analyzed data from 2,205 patients with acute non-lacunar ischemic strokes, focusing on four specific genetic variants (SNPs) of the ABCC8 gene.
- The findings revealed no significant link between these SNPs and stroke infarct size or 3-month functional outcomes, suggesting the need for more thorough investigations with improved imaging and outcome assessments.
Introduction: Large genome-wide association studies (GWASs) using case-control study designs have now identified tens of loci associated with ischemic stroke (IS). As a complement to these studies, we performed GWAS in a case-only design to identify loci influencing the age at onset (AAO) of ischemic stroke.
Methods: Analyses were conducted in a discovery cohort of 10,857 ischemic stroke cases using a linear regression framework.
Objective: Although stroke incidence is decreasing in older ages, it is increasing in young adults. While these divergent trends in stroke incidence are at least partially attributable to diverging prevalence trends in stoke risk factors, age-dependent differences in the impact of stroke risk factors on stroke may also contribute. To address this issue, we utilized Mendelian Randomization (MR) to assess differences in the association of stroke risk factors between early onset ischemic stroke (EOS) and late onset ischemic stroke (LOS).
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