Publications by authors named "S J Kempin"
: Prostate cancer (PC) and its treatment are often associated with side effects such as fatigue, muscle loss, and diminished quality of life (QoL). Physical exercise, particularly resistance training (RT) and aerobic training (AT), has been suggested as a strategy to mitigate these effects. However, the comparative efficacy of RT, AT, and combined RT/AT on QoL, body composition, physical fitness, and laboratory markers in PC patients is still insufficiently understood.
View Article and Find Full Text PDFExercise improves the insulin sensitivity of glucose uptake in skeletal muscle. Due to that, exercise has become a cornerstone treatment for type 2 diabetes mellitus (T2DM). The mechanisms by which exercise improves skeletal muscle insulin sensitivity are, however, incompletely understood.
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- Patients with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL) participated in a phase 2 trial (E2903) studying a chemotherapy regimen involving pentostatin, cyclophosphamide, and rituximab (PCR), followed by alemtuzumab.
- The trial enrolled 102 patients with a median age of 64, showing an overall response rate of 55%, but only 6% achieved major responses (complete or nodular partial remission).
- Despite PCR being effective and generally well-tolerated, the addition of alemtuzumab did not significantly enhance responses or overall survival for those with minor responses or stable disease.