Publications by authors named "S J Kao"
Platinum-based chemotherapy in combination with anti-PD-L1 antibodies has shown promising results in mesothelioma. However, the immunological mechanisms underlying its efficacy are not well understood and there are no predictive biomarkers to guide treatment decisions. Here, we combine time course RNA sequencing (RNA-seq) of peripheral blood mononuclear cells with pre-treatment tumor transcriptome data from the single-arm, phase 2 DREAM trial (N = 54).
View Article and Find Full Text PDFPediatric neurological injury and disease is a critical public health issue due to increasing rates of survival from primary injuries (e.g., cardiac arrest, traumatic brain injury) and a lack of monitoring technologies and therapeutics for treatment of secondary neurological injury.
View Article and Find Full Text PDFBackground: Low-dose computed tomography (LDCT) has been widely adopted for lung cancer screening due to its proven ability to reduce lung cancer mortality, especially among high-risk populations.
Methods: This retrospective study aims to evaluate the impact of LDCT screening on non-small cell lung cancer (NSCLC) staging at Kaohsiung Medical University Hospital (KMUH) from 2011 to 2020, following the introduction of LDCT in 2013. The study examines the correlation between LDCT screening volume and changes in the distribution of NSCLC stages, particularly early-stage (stages 0 and I) and late-stage (stage IV) diagnoses.
Article Synopsis
- - The study showcases a new method called transverse selective-zoning to achieve all-optical quasi-phase matching (QPM) in high-order harmonic generation (HHG).
- - Researchers identified key parameters like dephasing length by using tomographic techniques and applied a disruptive pulse to control harmonic emission in specific regions.
- - The approach resulted in a 35% increase in output using one QPM zone, demonstrating the potential for this technique to improve HHG efficiency, especially for higher energies where traditional phase matching is challenging.