Publications by authors named "S J Kahn"
Impact of self-reported race on Villalta Scale postthrombotic syndrome scores and correlation with venous disease-specific quality of life: an exploratory analysis of the Acute Venous Thrombosis: Thrombus Removal with Adjunctive Catheter-Directed Thrombolysis Trial.
Res Pract Thromb Haemost
November 2024
Article Synopsis
- - The study examined how the Villalta Scale (VS) for diagnosing postthrombotic syndrome (PTS) varied between self-reported Black and White patients in a trial focused on improving outcomes after deep vein thrombosis (DVT).
- - Results showed that while overall VS scores were similar between the two racial groups, Black participants had a significantly lower score for one specific sign (venous ectasia), indicating potential differences in symptom reporting or clinician evaluation.
- - The study highlights potential racial disparities in the assessment of PTS symptoms and suggests the need for further investigation into how race may influence clinician ratings and patient experiences.
Background: The optimal management of patients with intermediate-risk pulmonary embolism (PE), who have right heart dysfunction (determined by a combination of imaging and cardiac biomarkers) but a normal blood pressure, is uncertain. These patients suffer from reduced functional capacity and a lower quality of life over the long-term, despite use of anticoagulant therapy. Catheter-directed therapy (CDT) is a promising treatment for acute PE that rapidly removes thrombus and potentially improves cardiac dysfunction.
View Article and Find Full Text PDFLentiviral vectors that facilitate gene delivery to desired cell types have been widely used in routine laboratory research and therapeutic cell engineering. However, the lack of proper entry receptors on many cell types often results in poor gene delivery. Here, we present a simple paired virus-cell engineering approach that promotes lentiviral gene delivery into mammalian cells.
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