Contact-Engineered Oxide Memtransistors for Homeostasis-Based High-Linearity and Precision Neuromorphic Computing.

Homeostasis is essential in biological neural networks, optimizing information processing and experience-dependent learning by maintaining the balance of neuronal activity. However, conventional two-terminal memristors have limitations in implementing homeostatic functions due to the absence of global regulation ability. Here, three-terminal oxide memtransistor-based homeostatic synapses are demonstrated to perform highly linear synaptic weight update and enhanced accuracy in neuromorphic computing.

Emerging regulatory mechanisms and functions of biomolecular condensates: implications for therapeutic targets.

Cells orchestrate their processes through complex interactions, precisely organizing biomolecules in space and time. Recent discoveries have highlighted the crucial role of biomolecular condensates-membrane-less assemblies formed through the condensation of proteins, nucleic acids, and other molecules-in driving efficient and dynamic cellular processes. These condensates are integral to various physiological functions, such as gene expression and intracellular signal transduction, enabling rapid and finely tuned cellular responses.

Role of the Notch signaling pathway in porcine oocyte maturation.

Background: Although the Notch signaling pathway is known to play an important role in ovarian follicle development in mammals, whether it is involved in oocyte maturation remains unclear. Therefore, this study was performed to elucidate the existence and role of the Notch signaling pathway during oocyte maturation in a porcine model.

Methods: Reverse transcription-polymerase chain reaction (RT-PCR) and immunocytochemical assays were used to determine the existence of Notch signaling pathway-related transcripts and proteins in porcine cumulus-oocyte complexes (COCs).

Predicting depressive symptoms in employees through life stressors: subgroup analysis by gender, age, working hours, and income level.

Background: Although evidence has accumulated regarding the association between various stressors and depression, few studies have considered the context in which multiple stressors coexist simultaneously. Thus, this study aimed to evaluate the relative importance of seven major life stressors on depressive symptoms: workplace stress, family relationships, interpersonal conflicts, health problems, financial strains, traumatic events, and mannerisms, and analyzed its variation in subgroups.

Methods: Data from 12,541 Korean employees were analyzed.