Publications by authors named "S J Jadhao"
Background: Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory infections in children <2 years of age. Prior infection in a child is usually determined by RSV antibodies; however, in young children, persisting maternal immunoglobulin G antibodies can incorrectly indicate past RSV infection. We developed and evaluated 4 immunoglobulin A (IgA) antibody enzyme immunoassays (EIAs) with the RSV F, subgroup G (Ga or Gb proteins) or RSV lysate antigens to distinguish infection induced from persisting maternal RSV antibodies.
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- The study investigated the resistance of Rhipicephalus microplus ticks in Maharashtra, India, to synthetic pyrethroids, cypermethrin and deltamethrin, revealing all isolates tested were resistant to deltamethrin, with varying resistance levels across different regions.
- It found significant increases in the activity of α- and β-esterase enzymes in treated larvae, suggesting a biochemical response to these insecticides, with specific isolates showing notably high enzyme activity after exposure.
- The findings indicate that both deltamethrin and cypermethrin are ineffective for tick control in the region, prompting recommendations for stricter regulation of these compounds and the development of alternative tick control strategies.
Background: Respiratory syncytial virus (RSV) is a leading cause of acute respiratory illness (ARI) in older adults. Optimizing diagnosis could improve understanding of RSV burden.
Methods: We enrolled adults ≥50 years of age hospitalized with ARI and adults of any age hospitalized with congestive heart failure or chronic obstructive pulmonary disease exacerbations at 2 hospitals during 2 respiratory seasons (2018-2020).
Diagnosing lung infections is often challenging because of the lack of a high-quality specimen from the diseased lung. Since persons with cystic fibrosis are subject to chronic lung infection, there is frequently a need for a lung specimen. In this small, proof of principle study, we determined that PneumoniaCheck, a non-invasive device that captures coughed droplets from the lung on a filter, might help meet this need.
View Article and Find Full Text PDFBackground: We report an obstetric case involving an RhD-positive woman who had developed a red blood cell (RBC) antibody that was not detected until after delivery of a newborn, who presented with a positive direct antiglobulin test result. Immunohematology studies suggested that the maternal antibody was directed against a low-prevalence antigen on the paternal and newborn RBCs.
Results: Comprehensive blood group profiling by targeted exome sequencing revealed a novel nonsynonymous single nucleotide variant (SNV) RHCE c.