Dynamically cultured, differentiated bovine adipose-derived stem cell spheroids as building blocks for biofabricating cultured fat.

Cultured or cultivated meat, animal muscle, and fat tissue grown in vitro, could transform the global meat market, reducing animal suffering while using fewer resources than traditional meat production and no antimicrobials at all. To ensure the appeal of cultured meat to future customers, cultured fat is essential for achieving desired mouthfeel, taste, and texture, especially in beef. In this work we show the establishment of primary bovine adipose-derived stem cell spheroids in static and dynamic suspension culture.

Methodological concerns underlying a lack of evidence for cultural heterogeneity in the replication of psychological effects.

The multi-site replication study, Many Labs 2, concluded that sample location and setting did not substantially affect the replicability of findings. Here, we examine theoretical and methodological considerations for a subset of the analyses, namely exploratory tests of heterogeneity in the replicability of studies between "WEIRD and less-WEIRD cultures". We conducted a review of literature citing the study, a re-examination of the existing cultural variability, a power stimulation for detecting cultural heterogeneity, and re-analyses of the original exploratory tests.

Activation of the aryl hydrocarbon receptor improves allergen-specific immunotherapy of murine allergic airway inflammation: a novel adjuvant option?

Background: Allergen-specific immunotherapy (AIT) is able to restore immune tolerance to allergens in allergic patients. However, some patients do not or only poorly respond to current treatment protocols. Therefore, there is a need for deeper mechanistic insights and further improvement of treatment strategies.

Seasonal dynamics of the standard test species Lemna sp. in outdoor microcosms.

Lemna L. sp. is a free-floating aquatic macrophyte that plays a key role as a standard test species in aquatic risk assessment for herbicides and other contaminants.