Publications by authors named "S J H Wielders"
Article Synopsis
- This study analyzes how different platelet collagen receptors (GPVI, α2β1, and GPIb-IX-V) interact with various sources of collagen, impacting platelet activation and thrombus formation.
- Ethical collagens tested include type I collagen from equine tendon, rat tail, and acid-soluble collagen from human umbilical cord.
- The results show varied reliance on receptors for platelet aggregation depending on the collagen type, with GPVI playing a crucial role in reducing thrombus parameters when inhibited, demonstrating that collective receptor interactions influence platelet behavior on different collagen surfaces.
Background: In addition to the elimination diet, dietary composition may influence disease severity in patients with eosinophilic esophagitis (EoE) through modulation of the immune response.
Aim: To explore the immunomodulatory role of nutrition before and during elimination diet in adult EoE patients.
Methods: Nutritional intake was assessed in 39 Dutch adult EoE patients participating in the Supplemental Elemental Trial (Dutch trial registry NL6014, NTR6778) using 3-day food diaries.
Introduction: Studying arterial thrombus formation by flow assays is a widely used approach. Incorporating human atherosclerotic plaque material as a thrombogenic surface in these assays represents a method to model the pathophysiological environment of thrombus formation upon plaque disruption. Up until now, achieving a homogeneous coating of plaque material and subsequent reproducible platelet adhesion has been challenging.
View Article and Find Full Text PDFUnlabelled: Essentials The C-terminus of tissue factor pathway inhibitor (TFPIα) binds to the B-domain of factor V (FV). The functional consequences of this interaction were investigated in plasma and model systems. The TFPIα C-terminus inhibited thrombin generation in plasma, but not in the presence of FVa.
View Article and Find Full Text PDFObjective: Animal models suggest that toll-like receptor 9 (TLR9) promotes thrombus resolution after acute deep venous thrombosis (DVT). We hypothesized that TLR9 expression is lower in patients with post-thrombotic syndrome (PTS) and investigated the role of TLR9 in residual thrombosis (RT) and recurrence.
Methods: Patients with a history of DVT with PTS (cases, n=30) and without PTS after minimal 24 months follow-up (controls, n=30) were selected.