Publications by authors named "S J Ginsberg"
Article Synopsis
- Both Down syndrome (DS) and Alzheimer's disease (AD) show selective vulnerability in certain neuron populations, particularly affecting memory and executive functions through degeneration of pyramidal neurons (PNs).
- Research used RNA-sequencing to analyze PNs in the prefrontal cortex (specifically Brodmann area 9) in postmortem brains from individuals with DS and matched controls, revealing significant gene dysregulation that differs between two layers of neurons.
- Findings indicate that DS impacts gene regulation specifically in different neuron layers, with layer III showing more unique dysregulation relevant to early AD, suggesting potential pathways for understanding the relationship between DS and AD.
Article Synopsis
- Parkinson's disease (PD) is linked to inflammation, and researchers studied brain cells in late-stage PD using advanced techniques to understand vulnerabilities.
- They analyzed brain samples from six PD patients and six healthy controls, identifying distinct changes in eight cell types, including increased T cells in PD and marked alterations in excitatory neurons.
- Comparisons with Alzheimer's disease revealed that while neuron changes were different, both diseases shared some changes in glial cells, indicating unique underlying mechanisms for neuronal vulnerability in PD versus AD.
The intricate network of protein-chaperone interactions is crucial for maintaining cellular function. Recent discoveries have unveiled the existence of specialized chaperone assemblies, known as epichaperomes, which serve as scaffolding platforms that orchestrate the reconfiguration of protein-protein interaction networks, thereby enhancing cellular adaptability and proliferation. This study explores the structural and regulatory aspects of epichaperomes, with a particular focus on the role of post-translational modifications (PTMs) in their formation and function.
View Article and Find Full Text PDFDelirium is often the first symptom of incipient acute illness or complications and must therefore be detected promptly. Nevertheless, routine screening for delirium in acute care hospital wards is often inadequate. We recently implemented a simple, user-friendly delirium screening test (RMA) that can be administered during ward rounds and routine nursing care.
View Article and Find Full Text PDFArticle Synopsis
- * The study tested maternal choline supplementation (MCS) on a mouse model to see if it improves early endosome issues linked to these neurons.
- * Results showed MCS reduced early endosome numbers and sizes, improving their function, suggesting it could be an effective early intervention for DS and related disorders.