Publications by authors named "S J Geetha"
The field of crosslinking mass spectrometry has seen substantial advancements over the past decades, enabling the structural analysis of proteins and protein complexes and serving as a powerful tool in protein-protein interaction studies. However, data analysis of large non-cleavable crosslink studies is still a mostly unsolved problem due to its n-squared complexity. We here introduce an algorithm for the identification of non-cleavable crosslinks implemented in our crosslinking search engine MS Annika that is based on sparse matrix multiplication and allows for proteome-wide searches on commodity hardware.
View Article and Find Full Text PDFIntroduction: In this study we aim to analyze the TRPS1 immunostaining of salivary gland tumors (SGT) on cytology cell blocks and compare the staining pattern on subsequent surgical resections.
Methods: Malignant SGTs, oncocytomas and basal cell adenomas diagnosed on fine needle aspiration were retrieved from 2019 to 2021 database. Cases with surgical follow-up were selected.
Introduction: Indeterminate oncocytic/Hürthle cell lesions on thyroid cytology are reflexed to molecular testing. This study aims to examine the cytologic characteristics of thyroid fine-needle aspiration (FNA) smears with oncocytes classified as atypia of undetermined significance (AUS) with particular molecular patterns that can aid in determining a more conclusive Bethesda category upfront thus decreasing unnecessary testing and associated costs.
Materials And Methods: Our pathology database was searched for thyroid FNAs with AUS for oncocyte predominance from 2019 to 2022.
Introduction: Solid pseudopapillary neoplasm (SPN) is a tumor of young females with gain-of-function mutation in catenin beta 1 gene involved in Wnt signal transduction pathway. Beta-catenin immunohistochemistry (IHC) is used to diagnose SPN. Lymphoid enhancer-binding factor 1 (LEF-1) has been recognized in the transactivation of Wnt pathway.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates whether a higher post-procedure hematocrit (Hct) after red cell exchange in sickle cell disease (SCD) affects reticulocyte counts, which are important for predicting SCD complications.
- Researchers analyzed data from 17 patients who underwent two types of red cell exchange procedures and found that post-procedure Hct levels were not linked to changes in reticulocyte counts or sickle hemoglobin levels.
- The study suggests that factors like gender and white blood cell counts may influence reticulocyte counts, and recommends considering different treatment approaches, such as isovolemic hemodilution or hydroxyurea, for patients with elevated blood cell counts