Analysis of Immunological Memory for John Cunningham Virus in a Mexican Population of Patients with Multiple Sclerosis Under Treatment.

: Multiple sclerosis (MS) is a disease characterized by demyelination and axonal damage of the central nervous system. Despite the observed benefits, highly effective treatment (HET)-based therapy has adverse effects, which include an increased risk of developing progressive multifocal leukoencephalopathy (PML). Additionally, the risk grows if the patient has antibodies for the John Cunningham virus (JCV).

[Updates in General Management and Frequent Complications Following Adult Liver Transplant].

Liver transplantation (LT) is a cost-effective therapy for advanced liver disease. Although LT significantly improves long-term survival, it requires strict control of immunosuppressants and their potential complications. Several available immunosuppressive drugs include glucocorticoids, calcineurin inhibitors, mycophenolate, mTOR inhibitors, and anti-CD25 antibodies.

Skull base meningiomas: A bibliometric analysis and comprehensive overview of clinical reports.

Background: Skull-base surgery, including skull-base meningiomas (SBMs), is among the most challenging medical fields which has witnessed leaps in advancement, owing to ever evolving technological and scientific progress. We performed a comprehensive bibliometric analysis and analysis of clinical reports on SBMs to describe the evolution and identify trends and relationships between basic and applied research in the field.

Methods: The study was a qualitative and quantitative bibliometric analysis of SBM research and review of SBM clinical series via a systematic search of the Web of Science for SBM topics and SBM case series.

Two decades of bacterial ecology and evolution in a freshwater lake.

Ecology and evolution are considered distinct processes that interact on contemporary time scales in microbiomes. Here, to observe these processes in a natural system, we collected a two-decade, 471-metagenome time series from Lake Mendota (Wisconsin, USA). We assembled 2,855 species-representative genomes and found that genomic change was common and frequent.