Revisiting the bi-factor structure of the short version of the Warwick-Edinburgh mental well-being scale with samples in China.

Aim: This paper aims to evaluate the factor structure and psychometric properties of the Short Warwick-Edinburgh Mental Well-being Scale (SWEMWBS) based on Chinese samples recruited from secondary schools, universities, and workplaces.

Methods: The psychometric properties of the SWEMWBS were evaluated in four cross-sectional studies with a total of 1,729 respondents from Hong Kong and Chinese mainland. Criterion validity was assessed using well-established measures of well-being, affect, and life satisfaction (PANAS, WHO-5, and SWLS).

Factors Influencing Initial Rehabilitation Type After Hip Fracture Surgery: A Retrospective Cohort Study.

Objective: To describe and compare the factors that impact initial rehabilitation type after hip fracture surgery.

Design: Retrospective population-based cohort study.

Setting And Participants: People aged between 50 and 105 with a hip fracture who had a surgical repair in Ontario, Canada, between January 1, 2015, and December 31, 2021.

Promotion of NLRP3 autophagosome degradation by PV-K nanodevice for protection against macrophage pyroptosis-mediated lung injury.

Acute respiratory distress syndrome (ARDS) has emerged as a significant global health challenge, with no definitive curative treatment available. Recent evidence suggests that pyroptosis of immune cells plays a pivotal role in the pathogenesis of ARDS. Targeting and modulating immune cell pyroptosis in lung tissue may offer a promising strategy to mitigate the harmful inflammation associated with this condition.

Use of Feeding Tubes Among Hospitalized Older Adults With Dementia.

Importance: Although dementia is a contraindication for feeding tube placement, guidelines recommending against its use are inconsistently followed, and factors associated with its use are unclear.

Objective: To describe the incidence of feeding tube placement among hospitalized older adults (aged ≥65 years) with dementia and their health outcomes during and after hospitalization and to identify factors associated with placement of feeding tubes (ie, gastrostomy, gastrostomy-jejunostomy, and jejunostomy tubes).

Design, Setting, And Participants: This population-based retrospective cohort study was conducted using a linked database in Ontario, Canada.

Rezafungin: A Review in Invasive Candidiasis.

Rezafungin (Rezzayo) is a next-generation echinocandin antifungal with improved pharmacokinetic properties over first-generation echinocandins that allows for once-weekly rather than once-daily intravenous administration. It has recently been approved for the treatment of adults with invasive candidiasis in the EU and UK, and is approved for adults who have limited or no alternative options for the treatment of candidaemia and invasive candidiasis in the USA. In the pivotal phase 3 ReSTORE trial, rezafungin was non-inferior to caspofungin (a first-line echinocandin antifungal agent) based both on global cure rates at day 14 and all-cause mortality rates at day 30 in adults with candidaemia or invasive candidiasis.