Publications by authors named "S J FitzGibbon"
Management strategies, such as assisted gene flow, can increase resilience to climate change in tree populations. Knowledge of evolutionary history and genetic structure of species are needed to assess the risks and benefits of different strategies. , or Island Oak, is a rare oak restricted to six Channel Islands in California, United States, and Baja California, Mexico.
View Article and Find Full Text PDFReference genomes are foundational to modern genomics. Our growing understanding of genome structure leads to continual improvements in reference genomes and new genome "builds" with incompatible coordinate systems. We quantified the impact of genome build on germline and somatic variant calling by analyzing tumour-normal whole-genome pairs against the two most widely used human genome builds.
View Article and Find Full Text PDFArticle Synopsis
- - Sarcomas are rare tumors with over 100 subtypes, making it challenging to find effective therapies; there's a need for personalized treatment approaches to enhance patient outcomes.
- - Patient-derived tumor organoids (PDTOs) were used to study drug resistance and sensitivity in sarcoma, analyzing 194 specimens from 126 patients across 24 subtypes.
- - The research developed a high-throughput screening method that provided results quickly and showed that drug sensitivity linked to tumor characteristics; 59% of samples matched with at least one effective FDA-approved treatment.
Article Synopsis
- Advances in DNA sequencing technology have made it faster and more affordable, leading to improved data availability and the need for complex algorithms and workflows.
- Metapipeline-DNA is a customizable and flexible analysis pipeline that handles various processing tasks like read alignment, variant calling, and quality control, making it easier to analyze DNA sequencing data.
- This open-source tool is available under the GPLv2 license and can be accessed for free at https://github.com/uclahs-cds/metapipeline-DNA.
Background: Electroencephalography (EEG) can be used in neonates to measure brain activity changes that are evoked by noxious events, such as clinically required immunisations, cannulation and heel lancing for blood tests. EEG provides an alternative approach to infer pain experience in infants compared with more commonly used behavioural and physiological pain assessments. Establishing the generalisability and construct validity of these measures will help corroborate the use of brain-derived outcomes to evaluate the efficacy of new or existing pharmacological and non-pharmacological methods to treat neonatal pain.
View Article and Find Full Text PDF