Publications by authors named "S J E Lucas"

Introduction: Worldwide, 2.4 billion people rely on solid fuels such as wood or charcoal for cooking, leading to approximately 3.2 million deaths per year from illnesses attributable to household air pollution.

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Exercise training has been proposed to counteract age-related cognitive decline through improvements in cardiorespiratory fitness (CRF hypothesis). Research has focused on cognitive domains like attention and processing speed, and one cross-sectional study reported a positive relationship between CRF and language production in older adults. In a randomized controlled trial, we investigated whether these benefits could extend to language comprehension in healthy older adults, and whether bilinguals, for whom language processing is more costly, would exhibit greater benefits than monolinguals.

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Article Synopsis
  • BFL1, an antiapoptotic protein from the BCL2 family, is linked to hematological cancers but hasn't been extensively researched.
  • Two articles present the development of selective BFL1 inhibitors, starting from hit identification using a covalent fragment library and leading to optimized compounds.
  • One compound not only induced cell death in specific cancer cell lines but also stabilized the BFL1 protein, significantly increasing its half-life to 10.8 hours while activating cellular apoptosis markers.
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This review aims to raise awareness about the prevalence and impact of pediatric anxiety, emphasizing the need for clinician education in primary care and mental health settings. Early detection and management of pediatric anxiety can be achieved through the development and implementation of standardized screening protocols. Our goal is to positively improve the outcomes of pediatric patients suffering from anxiety by improving the awareness and knowledge of clinicians in primary and mental health care settings.

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