Publications by authors named "S J Deharvengt"
Article Synopsis
- * A pilot program was launched where pharmacists reviewed genetic test results, provided drug-dosing advice, and documented interactions in patient records, which were shared with oncologists.
- * Results showed that out of 71 patients, 21 had actionable genetic variants, leading to dose changes in five patients, demonstrating the potential of pharmacist involvement in personalized medicine.
Molecular analysis plays a growing role in the diagnosis of mesenchymal neoplasms. The aim of this study was to retrospectively apply broad, multiplex molecular assays (a solid tumor targeted next-generation sequencing [NGS]) assay and single nucleotide polymorphism [SNP] microarray) to selected tumors, exploring the current utility and limitations. We searched our database (2010-2020) for diagnostically challenging mesenchymal neoplasms.
View Article and Find Full Text PDFArticle Synopsis
- Scientists studied gliomas, which are types of brain tumors, to see how changes in genes can affect how long patients live and how likely their cancer is to come back.
- They looked at tissue samples from 293 patients to find specific gene mutations and other changes that might predict patient outcomes.
- The findings showed that some gene mutations, like IDH1 and MGMT, were linked to better survival rates, while others, like FLT3 and TP53, were linked to worse outcomes.
Introduction: Activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor () gene in non-small cell lung cancer (NSCLC) patients predicts response to EGFR tyrosine kinase inhibitors (TKIs). The Idylla™ system (Biocartis, Mechelen, Belgium) is a fully integrated, cartridge-based platform that provides automated sample processing and real-time PCR-based mutation detection in a single-use cartridge. This study evaluated the Idylla™ EGFR Mutation Assay cartridges against next-generation sequencing (NGS) using formalin fixed, paraffin embedded (FFPE) lung cancer tissue samples.
View Article and Find Full Text PDF