Publications by authors named "S J Coughlan"
Article Synopsis
- Carbapenemase-producing Enterobacterales (CPE) are multidrug-resistant bacteria that can spread their resistance genes via mobile genetic elements, complicating infection control efforts.
- A study in Galway, Ireland involved whole-genome sequencing of CPE samples from patients and wastewater to understand the distribution and characteristics of these organisms and their resistance genes.
- Findings revealed that most resistance genes were found on plasmids, with specific plasmid types associated with different CPE strains, highlighting the genetic mechanisms facilitating the spread of resistance between humans and the environment.
Article Synopsis
- Foodborne transmission of Hepatitis E virus (HEV) is a growing public health issue in China, with pig liver identified as a potential source of contamination.
- A study tested 787 pig liver samples from various markets in 7 provinces and found an overall HEV positive rate of 8.13%, with Inner Mongolia and Hebei showing the highest rates.
- Different market types (wholesale, supermarket, butcher's shop) had varying positive rates, but no significant differences were found between them; specific genotypes of HEV were identified in several samples.
Purpose: To understand how best to assess the language abilities of preterm-born children, this study: (a) compared preterm- and term-born children's language skills using standardized testing and language sample analysis (LSA), (b) investigated how executive function skills and the language sampling context respectively affect standardized test and LSA scores, and (c) examined the pattern of associations between standardized test and LSA scores among preterm-/term-born groups.
Method: Twenty-five term-born and 23 preterm-born 2-year-old singletons were administered the language scales of the Bayley Scales of Infant and Toddler Development-Third Edition (receptive communication, expressive communication, language composite scores). Parent-child free-play recordings were used to quantify the (para)linguistic features of the children's speech.
Drugs that block DNA replication prevent cell proliferation, which may result in anticancer activity. The latter is dependent on the drug's mode of action as well as on cell type-dependent responses to treatment. The inhibition of Cell division cycle 7-related protein kinase (CDC7), a key regulator of DNA replication, decreases the efficiency of origin firing and hampers the restarting of paused replication forks.
View Article and Find Full Text PDFPurpose: To investigate the language environments experienced by preterm-born infants, this study compared the linguistic and interactive features of parent-infant conversations involving 2-year-old preterm- and term-born infants. The study also explored how mother-infant and father-infant conversations may be differentially affected by preterm/term birth status.
Method: Twenty-two preterm-born (< 37 weeks' gestation) and 25 term-born (≥ 37 weeks' gestation) 2-year-old infants engaged in dyadic mother/father-infant free-play interactions that were transcribed to quantify the linguistic (parental volubility, speech rate, lexical diversity, and morphosyntactic complexity) and interactive (infant/parent responsiveness, turn-taking, and conversational balance) features of parent-infant conversations.