A deep multiple instance learning framework improves microsatellite instability detection from tumor next generation sequencing.

Microsatellite instability (MSI) is a critical phenotype of cancer genomes and an FDA-recognized biomarker that can guide treatment with immune checkpoint inhibitors. Previous work has demonstrated that next-generation sequencing data can be used to identify samples with MSI-high phenotype. However, low tumor purity, as frequently observed in routine clinical samples, poses a challenge to the sensitivity of existing algorithms.

Correction: Atypical Multi-ligamentous Knee Injury (aMLKI): Binary Injury with Avulsion of One Cruciate and Tear of the Other, or Bi-cruciates Avulsion with or Without Collateral Ligament Injury Following Road Traffic Accidents (RTA).

[This corrects the article DOI: 10.1007/s43465-024-01256-7.].

Integration of Ayurvedic and Allopathic treatment in hereditary breast and ovarian cancer patient with Germline BRCA1 mutation for long term disease free survival: A case report.

Ovarian cancer patients with BRCA1 mutation have more susceptibility for secondary breast cancer. In females with BRCA1 mutation, the risk of developing breast carcinoma is 65% and of ovarian cancer is 39%, before 70 years of age. This is a case report of a 74 year old, post-menopausal woman diagnosed with metastatic retroperitoneal lymph node, high-grade papillary adenocarcinoma primary ovary stage IIIA in April 2004 at the age of 48 years.

Evaluation of Early Childhood Caries and Its Association with Risk Factors among School Children: A Cross-sectional Study.

Aim: The study aimed to assess early childhood caries and its correlation with risk variables among school children.

Materials And Methods: 242 children under the age of 5 years were clinically assessed and to ascertain early childhood caries, a validated structured questionnaire was utilized. Demographic data (four questions) and oral health-related activities questions (two questions) were included.