Publications by authors named "S J CASTELLANO"
Background: Electrographic flow (EGF) mapping allows for the visualization of global atrial wavefront propagations. One mechanism of initiation and maintenance of atrial fibrillation (AF) is stimulation from EGF-identified focal sources that serve as driver sites of fibrillatory conduction. Electrographic flow consistency (EGFC) further quantifies the concordance of observed wavefront patterns, indicating that a healthier substrate shows more organized wavefront propagation and higher EGFC.
View Article and Find Full Text PDFA comprehensive study of common and rare genetic variants in spermatogenesis-related loci identifies new risk factors for idiopathic severe spermatogenic failure.
Hum Reprod Open
November 2024
Study Question: Can genome-wide genotyping data be analysed using a hypothesis-driven approach to enhance the understanding of the genetic basis of severe spermatogenic failure (SPGF) in male infertility?
Summary Answer: Our findings revealed a significant association between SPGF and the gene and identified three novel genes (, , and ) along with 32 potentially pathogenic rare variants in 30 genes that contribute to this condition.
What Is Known Already: SPGF is a major cause of male infertility, often with an unknown aetiology. SPGF can be due to either multifactorial causes, including both common genetic variants in multiple genes and environmental factors, or highly damaging rare variants.
Recently, the disease associated with antibodies against the myelin glycoprotein of oligodendrocytes was described. It is characterized by clinical manifestations such as optic neuritis, transverse myelitis, and acute disseminated encephalomyelitis, among others. It occurs in children and young adults.
View Article and Find Full Text PDFArticle Synopsis
- Electrographic flow (EGF) mapping is a technique used to understand how electrical signals move in the heart's atria, especially in relation to atrial fibrillation (AF) compared to normal sinus rhythm (SR).
- The study involved mapping electrical activity in the atria of ten patients, showing that EGF patterns differ significantly in AF, with lower electrographic flow consistency (EGFC) during AF compared to SR, indicating more chaotic activity.
- The findings suggest EGFC could serve as a valuable marker for assessing atrial health and myopathy, correlating with bipolar voltage measurements, which are commonly used to evaluate heart conditions.
Article Synopsis
- * A small library of dual modulators was created using 2-phenylindole structures, showing effectiveness in binding to TSPO and activating CA VII.
- * One promising compound demonstrated no cytotoxicity, stimulated TSPO function, activated CA VII, and increased expression of brain-derived neurotrophic factor, highlighting its potential for further development.