Publications by authors named "S J Brodsky"
We use analytic continuation to extend the gauge-gravity duality nonperturbative description of the strong force coupling into the transition, near-perturbative, regime where perturbative effects become important. By excluding the unphysical region in coupling space from the flow of singularities in the complex plane, we derive a specific relation between the scales relevant at large and short distances; this relation is uniquely fixed by requiring maximal analyticity. The unified effective coupling model gives an accurate description of the data in the nonperturbative and the near-perturbative regions.
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- Proteins are filtered from blood by the glomerular filtration barrier and then reabsorbed by proximal tubular epithelial cells (PTECs), which create tubular protein reabsorption droplets (TPRDs) from these proteins.
- A study analyzing 109 kidney biopsies found a negative correlation between albumin TPRDs and proteinuria, while positive correlations were observed between proteinuria and IgG TPRDs and acute tubular necrosis (ATN).
- The findings suggest that healthy PTECs are crucial for managing protein levels in urine, as their effectiveness declines with conditions like ATN, leading to increased proteinuria.
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- This study focuses on how DNA-binding domains in transcription factors recognize specific sequence motifs in genomes, but in reality, they only bind to a small fraction of these motifs due to interactions with other transcription factors.
- The researchers developed a new method to test TF binding in yeast cells, allowing them to analyze thousands of designed sequences and measure how various transcription factors interacted with clusters of these motifs.
- The findings suggest that most TF binding can be explained by their independent interactions with individual motifs rather than by cooperative interactions between them, challenging previous ideas about how these factors work together in the genome.
Article Synopsis
- - RBPs consist of RNA binding domains (RBDs) linked by intrinsically disordered regions (IDRs), which help with RNA binding by orienting RBDs and directly interacting with RNA.
- - The study utilized an RNA tagging technique to map how 16 RBPs bind to RNA in budding yeast, performing mutations to analyze the roles of both RBDs and IDRs.
- - Findings revealed that many RBDs are not crucial for mRNA binding, while several IDRs without clear RNA binding features are essential for binding affinity and specificity, highlighting the complexity of RBP-RNA interactions.
Activation domains (ADs) within transcription factors (TFs) induce gene expression by recruiting coactivators such as the Mediator complex. Coactivators lack DNA binding domains (DBDs) and are assumed to passively follow their recruiting TFs. This is supported by direct AD-coactivator interactions seen in vitro but has not yet been tested in living cells.
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