Publications by authors named "S J Braak"
Background: The use of two-dimensional (2D) ultrasound for guiding radiofrequency ablation (RFA) of benign thyroid nodules presents limitations, including the inability to monitor the entire treatment volume and operator dependency in electrode positioning. We compared three-dimensional (3D)-guided RFA using a matrix ultrasound transducer with conventional 2D-ultrasound guidance in an anthropomorphic thyroid nodule phantom incorporated additionally with temperature-sensitive albumin.
Methods: Twenty-four phantoms with 48 nodules were constructed and ablated by an experienced radiologist using either 2D- or 3D-ultrasound guidance.
Article Synopsis
- Social dysfunction is a common feature of neuropsychiatric disorders like Schizophrenia and Alzheimer's disease, impacting socioaffective neural processing.
- A study analyzed how social dysfunction correlates with brain system activity in SZ and AD patients through fMRI tasks, revealing patterns related to emotional responses.
- The research found that severe behavioral social dysfunction linked to hyperactivity and hypoactivity in specific brain regions, highlighting the potential for tailored care based on individual social behavior.
The pursuit for markers of disease progression in behavioral variant frontotemporal dementia: a scoping review to optimize outcome measures for clinical trials.
Front Aging Neurosci
May 2024
Behavioral variant frontotemporal dementia (bvFTD) is a neurodegenerative disorder characterized by diverse and prominent changes in behavior and personality. One of the greatest challenges in bvFTD is to capture, measure and predict its disease progression, due to clinical, pathological and genetic heterogeneity. Availability of reliable outcome measures is pivotal for future clinical trials and disease monitoring.
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- Needle-based procedures for thyroid nodules, like fine needle aspiration and thermal ablation, carry risks of damaging nearby blood vessels and nerves.
- This study developed a single-use anthropomorphic phantom that accurately mimics the thyroid and its surroundings to test and validate ultrasound-guided thermal radiofrequency ablation procedures.
- Results showed the phantom's physical properties and responses to ablation were successful, with optimal ablation achieved while sparing critical structures.*
Introduction: Outcomes following tumor resection vary dramatically among patients with pancreatic ductal adenocarcinoma (PDAC). A challenge in defining predictive biomarkers is to discern within the complex tumor tissue the specific subpopulations and relationships that drive recurrence. Multiplexed immunofluorescence is valuable for such studies when supplied with markers of relevant subpopulations and analysis methods to sort out the intra-tumor relationships that are informative of tumor behavior.
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