Publications by authors named "S J Bourke"
Food for thought: more explicit guidance for inclusion of caregiver perspectives in health technology assessment.
Int J Technol Assess Health Care
December 2024
Article Synopsis
- - Caregivers play a crucial role in supporting individuals with serious health conditions, but this responsibility can lead to various financial, physical, and emotional challenges for them.
- - Health technology assessment (HTA) agencies usually focus on patient outcomes while neglecting the impact on caregivers, which can result in suboptimal health benefits for the overall system.
- - A proposed framework based on the intensity and duration of caregiving aims to help researchers and decision-makers incorporate caregiver outcomes into health policies, highlighting the necessity of acknowledging caregiver burden.
Background: Chronic neuropathic pain (CNP) is a debilitating condition, often refractory to currently available drugs. Understanding biochemical alterations in peripheral tissues such as blood will be useful for understanding underlying pathophysiological processes relating to CNP.
Methods: We collected blood from two independent cohorts of CNP and pain-free controls (CNP n = 129/Controls n = 127) in the UK and Ireland to investigate the relationship between CNP-associated molecular/biochemical alterations and a range of clinical and pain metric parameters.
Introduction: Exacerbation of COPD complicated by respiratory acidaemia is the commonest indication for noninvasive ventilation (NIV). The NIV outcomes (NIVO) score offers the best estimate of survival for those ventilated. Unfortunately, two-thirds of cases of COPD are unrecognised, and patients may present without COPD having been confirmed by spirometry.
View Article and Find Full Text PDFSpinal muscular atrophy (SMA) is a genetic neuromuscular disorder characterized by skeletal muscle weakness and atrophy. Patients with SMA types 1 and 2 develop severe disabilities conferring substantial patient and caregiver burden. Caregiver treatment characteristic preferences are useful for informing treatment choices and improving adherence.
View Article and Find Full Text PDFArticle Synopsis
- CAR-T therapy is a new way to treat blood cancers and is being looked at for other diseases and issues like solid tumors and aging.
- Traditional methods to create these CAR-T cells can hurt the cells or cause problems, making them less safe and effective.
- A new method called hydroporation helps make more healthy CAR-T cells quickly and efficiently, which could lead to better treatments for patients.