Structural Evidence for DUF512 as a Radical -Adenosylmethionine Cobalamin-Binding Domain.

Cobalamin (Cbl)-dependent radical -adenosylmethionine (SAM) enzymes constitute a large subclass of radical SAM (RS) enzymes that use Cbl to catalyze various types of reactions, the most common of which are methylations. Most Cbl-dependent RS enzymes contain an N-terminal Rossmann fold that aids Cbl binding. Recently, it has been demonstrated that the methanogenesis marker protein 10 (Mmp10) requires Cbl to methylate an arginine residue in the α-subunit of methyl coenzyme M reductase.

Pain Management for Older Adults Across the Cognitive Trajectory.

Purpose Of Review: This review investigated current research on the relationship between chronic pain and cognitive performance, subjective cognitive decline, and dementia. In addition, we reviewed current research on pain management in older adults across the cognitive trajectory.

Recent Findings: Chronic pain remains a common problem in older adults.

Foresight and Forecast: The Future of Gerontological Nursing for the Next 50 Years.

The World Health Organization recognizes that aging is a life-long process. Aging is a universal phenomenon, and the number of people aged ≥65 years is expected to increase exponentially over the next 30 to 50 years. Thus, the universality and globalization of aging requires that our interconnected societies be equipped to meet the needs of humans across all developmental and life stages.

Disparities, Inequities, and Injustices in Populations With Pain: Nursing Recommendations Supporting ASPMN's 2024 Position Statement.

The American Society for Pain Management Nursing (ASPMN) upholds the principle that all persons with pain have equal rights to evidence-based, high quality pain assessment, management, and treatment. This practice recommendation's goals are to 1) summarize known pain-related disparities, inequities, and injustices among commonly marginalized and at risk groups, 2) offer recommendations to ascertain that just and equitable pain care is provided to all people, and 3) outline a call to action for all nurses to embrace diversity, equity, inclusion, and a sense of belonging in order to mitigate pain-related disparities, inequities, and injustices within clinical environments and the nursing profession. This paper provides background and rationale for the 2024 ASPMN position statement on disparities, inequities and injustices in people with pain.