Publications by authors named "S J Bonacorsi"

Among 7578 cases of pediatric bacterial meningitis recorded in France (2001-2021), including 1313 neonatal cases, 23/7578 (0.3%) and 18/1313 (1.4%) were due to Citrobacter koseri.

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Introduction: Systemic sclerosis (SSc) is a connective tissue disease at the interface between inflammation and autoimmunity progressively leading to diffuse microvascular and fibrotic involvement of the skin and of multiple internal organs. Approximately, 20-40% of SSc patients suffer from cutaneous calcinosis, a debilitating manifestation due to calcium salt deposition in soft connective tissues, causing pain, ulceration, infection, and deformities, responsible of severe functional limitations. Pathomechanisms are poorly understood as well as markers/molecules capable to predict the risk of patients to develop calcinosis.

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Kingella kingae is a cause of bacteremia, endocarditis, and the leading cause of osteoarticular infections between 6 and 48 months of life. We report on a rare case of K. kingae meningitis in the absence of endocarditis and immune deficiency in a 26-month-old boy emphasizing the distinct genomic determinants of the strain which may be of importance to the pathogenesis of the disease.

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Article Synopsis
  • - The study focused on acute bacterial meningitis (ABM) cases in children, specifically analyzing instances without cerebrospinal fluid (CSF) pleocytosis, a condition where CSF has elevated leukocyte counts.
  • - Out of 4,754 ABM cases from 2001 to 2022 in France, only 173 (3.6%) lacked CSF pleocytosis, with a significant majority linked to meningococcal infections, and these cases showed a higher mortality rate (18% vs. 6%).
  • - The research concluded that while ABM without CSF pleocytosis is rare, it is critical, especially for children who experience seizures before hospital admission, suggesting that increased meningoc
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