Biological Medicines Prepared Using Vibration Processing Are Able to Influence Their Targets Without Direct Contact With Them.

Recently, there has been a radical change in understanding of the nature of drugs based on highly diluted solutions. It has been established that their activity does not depend on the content of the original substance in dilutions, but is a consequence of the technological processing (TP) of dilutions with vibration, which accompanies each dilution during the preparation of solutions and, among others, leads to the formation of nanoparticles with certain properties. Repeated vibration treatment leads to the appearance of modifying activity that is absent in the original substance, and these effects of TP solutions can be exerted without direct contact with their targets, which clearly indicates the physical nature of the TP solution's activity.

Generating porous metal surfaces as a mean to incorporate thymol-loaded nanoparticles.

Porous metals have gained interest in many fields such as biomedicine, electronics, and energy. Despite the many benefits that these structures may offer, one of the major challenges in utilizing porous metals is to incorporate active compounds, either small molecules or macromolecules, on these surfaces. Coatings that contain active molecules have previously been used for biomedical applications to enable the slow release of drugs, e.

[Ectopic thyroid gland: clinical features and diagnostics in children].

Background: BACKGROUND: The frequency of ectopia of thyroid gland among all types of dysgenesis varies from 30 to 70%, its most common localization is the root of the tongue. Otorhinolaryngologists, oncologists, pediatricians can take lingual ectopia for hypertrophy of the lingual tonsil or fibroma of the tongue root, which leads to unreasonable surgical treatment. Thyroid scintigraphy plays a key role in the diagnosis of ectopia.

[Predictors of the efficacy of radioiodine therapy of Graves' disease in children and adolescents].

Rationale: Insufficient world-wide clinical experience in radioiodine therapy (RIT) for Graves' disease (GD) in children and adolescents, and limited knowledge of the predictors of RIT efficacy.

Aims: Analysis and identification of the most significant predictors of the efficacy of RIT in children and adolescents with Graves' disease.

Materials And Methods: A total of 55 patients (48 females and 7 males) aged from 8 to 18 years receiving primary RIT for GD were enrolled.

[Holter monitoring for short-term prognostication in patients with myocardium infarction].

Individualized prognosis is a topical problem in the management of acute myocardial infarction. Prediction of clinical course and outcome of the disease encounters many difficulties since it requires highly sensitive and specific measurements that must be safe and technically simple. Prognostic studies related to acute myocardial infarction are many, but combined effect of various factors remains poorly known.