[Complex morphological approach to assessment of protective properties of preparations for cholera specific prophylaxis].

Using developed scheme, complex study of protective properties of avirulent recombinant strain Vibrio cholerae El Tor Inaba KM 184 was performed. Necessity for broadening of standard procedure of testing of cholera vaccines protective properties by using of quantitative methods of assessment of morphological changes and state of biomodel's functional systems, which could increase the information value of assessment of studied vaccines, was experimentally substantiated.

[A comparative cytofluorimetric analysis of the blood leukocytes in guinea pigs exposed to the phospholipase D and antigens of the causative agent of plague].

The influence of Y. pestis phospholipase D on the physiological state of leukocytes in the blood of guinea pigs was studied in vivo by flow impulse fluorometry with the use of fluorochrome acridine orange. During the first hours of observation the intensity of leukocyte fluorescence increased due to a rise in the number of polymorphonuclear leukocytes and changes in the permeability of cell membranes.

[The effect of different Yersinia pestis antigens on the cellular link in immunity].

Immunization with live plague vaccine has been shown to give no protection to thymectomized mice from subcutaneous challenge with Y. pestis virulent strain. Under the action of the vaccine or individual Y.

[The potentiating action of artificial immunodeficiency on the development of amyloidosis in plague in great gerbils].

Cyclophosphamide injection causes amyloidosis development in the spleen of great gerbils both intact and plague-infected after immunization. The amyloid deposits are observed irrespective of acquired antiplague resistance level. Alterations observed may be considered as acquired (secondary) AA-amyloidosis.