rac-(1S*,4aS*,8aS*)-4a-Hy-droxy-2-methyl-perhydro-spiro-[isoquinoline-4,1'-cyclo-hexa-n]-2'-one.

In the title compound, C15H25NO2, all three six-membered rings adopt chair conformations. The cyclo-hexane and piperidine rings within the perhydro-isoquinoline are trans-trans fused. The N atom has a trigonal-pyramidal geometry (the sum of the bond angles is 328.

Dimethyl 2-[23-oxo-22,24-diphenyl-8,11,14-trioxa-25-aza-tetra-cyclo-[19.3.1.0(2,7).0(15,20)]penta-cosa-2,4,6,15(20),16,18-hexaen-25-yl]but-2-enedioate.

The title compound, C(39)H(37)NO(8), is a product of the Michael addition of the cyclic secondary amine subunit of aza-14-crown-4 ether to dimethyl acetyl-enedicarboxyl-ate. The piperidinone ring exhibits a distorted chair conformation and the dimethyl acetyl-enedicarboxyl-ate fragment has a cis configuration with a dihedral angle of 56.61 (5)° between the two carboxyl-ate groups.

(2E,25E)-11,14,17,33,36,39,42-Hepta-oxa-penta-cyclo-[41.4.0.0.0.0]hepta-tetra-conta-1(43),2,5(10),6,8,18,20,22,25,27,29,31,44,46-tetra-decaene-4,24-dione.

The title compound, C(40)H(40)O(9), is a product of the double crotonic condensation of bis-(2-acetyl-phen-oxy)-3-oxapentane with bis-(2-formyl-phen-oxy)-3,6-dioxaoctane. The title macromolecule includes the 31-crown-7-ether skeletal unit and adopts a saddle-like conformation. The two ethyl-ene fragments have E configurations.

9-[(2-Hy-droxy-benzyl-idene)amino]-11-(2-hy-droxy-phen-yl)-10,13-diphenyl-8-oxa-12-azoniatricyclo-[7.3.1.0]trideca-2(7),3,5-triene acetate ethanol disolvate.

The title compound, C(36)H(31)N(2)O(3) (+),C(2)H(3)O(2) (-)·2C(2)H(5)OH, the product of a domino condensation of dibenzyl ketone with salicylic aldehyde and ammonium acetate, crystallized as the ethanol disolvate. The cation of the salt comprises a fused tricyclic system containing three six-membered rings (piperidine, dihydro-2H-pyran and benzene). The piperidine ring has the usual chair conformation, while the dihydro-pyran ring adopts a slightly distorted sofa conformation.

[Pathogenetic aspects of chlamydia-associated urogenic arthritis: feasibility of microorganism reproduction in cells of articular cartilage].

Aim: The study of feasibility of Chlamydia trachomatis infection and reproduction. This microorganism is an essential etiologic factor in urogenic arthritis, in chondrocytes and fibroblasts of human skin.

Materials And Methods: Infection of human skin chondrocytes and fibroblasts was made with chlamydia CP-1 strain isolated from joint fluid of the patient and serially passaged in the hen's embryo yolksacs.