Publications by authors named "S Iu Kozlova"
O-centered tetranuclear vanadium selenoiodide [VOSeI] (1) was synthesized by an ampoule method from the elements with addition of water. Its X-ray crystal structure (space group 2/, = 21.146(2) Å, = 5.
View Article and Find Full Text PDFThe combined or multivalent vaccines are actively used in pediatric practice and offer a series of advantages, including a reduced number of injections and visits to the doctor, simplicity of the vaccination schedule and minimization of side effects, easier vaccine monitoring and storage, and lower vaccination costs. The practice of widespread use of the combined vaccines has shown the potential to increase vaccination coverage against single infections. The mRNA platform has been shown to be effective against the COVID-19 pandemic and enables the development of combined vaccines.
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- Plasmid-borne Type II restriction-modification (RM) systems cause post-segregational killing (PSK) due to the loss of restriction and modification enzymes during cell division, leading to the breakdown of unmethylated DNA.
- A CRISPR interference method was developed to investigate PSK and found that different RM systems have distinct stability and recovery behaviors upon plasmid loss, particularly noting the Esp1396I system's limited duration of activity.
- This research suggests that the dynamics of RM systems and host cell growth rates are crucial for understanding PSK, highlighting the need to consider the lifetimes of system components in modeling these processes.
Seasonal influenza remains a serious global health problem, leading to high mortality rates among the elderly and individuals with comorbidities. Vaccination is generally accepted as the most effective strategy for influenza prevention. While current influenza vaccines are effective, they still have limitations, including narrow specificity for certain serological variants, which may result in a mismatch between vaccine antigens and circulating strains.
View Article and Find Full Text PDFSARS-CoV-2 variants have evolved over time in recent years, demonstrating immune evasion of vaccine-induced neutralizing antibodies directed against the original S protein. Updated S-targeted vaccines provide a high level of protection against circulating variants of SARS-CoV-2, but this protection declines over time due to ongoing virus evolution. To achieve a broader protection, novel vaccine candidates involving additional antigens with low mutation rates are currently needed.
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