[Cytogenetic action of a number of monohydric alcohols on bone marrow cells in rats].

Single administration of monohydric alcohols to rats in equitoxic doses corresponding to 1/5 LD50 results in a cytogenetic effect which depends on a chemical structure of the alcohol molecule. The isomers are less active chemicals than the normal counterparts.

[Mutagenic action of different alcohols in an experiment].

Ethanol, ethylene glycol and glycerine induce chromosomal aberrations in cells of the rat bone marrow and disturb a genetic apparatus of male sex cells at the stage of late spermatids. The cytogenetic activity of ethylene glycol depends on its dose. Phenobarbital stimulates the cytogenetic activity of ethanol and ethylene glycol.

[Embryotoxic and mutagenic activity of ethanol and acetaldehyde in intra-amniotic exposure].

The administration of acetaldehyde on the 13th day of pregnancy results in a considerable embryolethal effect, appearance of developmental abnormalities in rat embryos and chromosomal aberrations in fetal cells. Ethanol is found to have no teratogenic and mutagenic activity.