Publications by authors named "S Isomura"
Although oxytocin may provide a novel therapeutics for the core features of autism spectrum disorder (ASD), previous results regarding the efficacy of repeated or higher dose oxytocin are controversial, and the underlying mechanisms remain unclear. The current study is aimed to clarify whether repeated oxytocin alter plasma cytokine levels in relation to clinical changes of autism social core feature. Here we analyzed cytokine concentrations using comprehensive proteomics of plasmas of 207 adult males with high-functioning ASD collected from two independent multi-center large-scale randomized controlled trials (RCTs): Testing effects of 4-week intranasal administrations of TTA-121 (A novel oxytocin spray with enhanced bioavailability: 3U, 6U, 10U, or 20U/day) and placebo in the crossover discovery RCT; 48U/day Syntocinon or placebo in the parallel-group verification RCT.
View Article and Find Full Text PDFPhysical symptoms such as fatigue and muscle weakness, and psychiatric symptoms like depression and anxiety are considered as complications and sequelae of COVID-19. This epidemiological study investigated the actual status of psychiatric symptoms and disorders caused by COVID-19, from four major university hospitals and five general hospitals in Fukuoka Prefecture, Japan, having a population of 5 million. We conducted a survey of psychiatric disorders associated with COVID-19 using Diagnosis Procedure Combination (DPC) data and the psychiatric records of the hospitals.
View Article and Find Full Text PDFBackground: The Edinburgh postnatal depression scale (EPDS) is commonly used in screening for major postpartum depression (PPD). We explored the clinical factors associated with score changes.
Methods: Mothers (n=1,287) who delivered a single live-born infant in Kokura Medical Center in Japan during 2018-2019 were analyzed.
Article Synopsis
- The success of endovascular aortic aneurysm repair (EVAR) heavily relies on how well the endograft attaches to the aortic wall, particularly in cases of challenging neck anatomy (HNA).
- The AORFIX technique effectively aligns the stent end with the renal artery's orifice, showing significant benefits, such as higher rates of renal angioplasty and stenting (88% vs. 4.6%) compared to the standard approach, without any deaths within 30 days.
- Despite facing more complex HNA criteria, both groups experienced 100% procedural success, suggesting that the AORFIX technique may be a viable option for patients with difficult neck anatomy in EVAR