Publications by authors named "S Isloor"
Integrating one health strategies for rabies control: Insights from Jackal-mediated human rabies in Northeast India.
Comp Immunol Microbiol Infect Dis
November 2024
Introduction: Rabies is an ancient, lethal zoonotic disease caused by viruses of the genus Lyssavirus, affecting a wide variety of mammals. Though domestic dogs are the main vectors of rabies transmission to humans, other domestic and wildlife species also contribute to the spread of the disease in endemic regions like India. This report presents a case of human rabies following jackal exposure in India, along with the molecular characterization of the rabies virus (RABV) from both the jackal and the affected human patient.
View Article and Find Full Text PDFArticle Synopsis
- * ELISA has been suggested as an easier alternative but struggles with antigen availability, particularly RABV glycoprotein, which requires high biosafety levels for use.
- * The research tested insect cell extracts producing RABV glycoprotein and found it effectively detected rabies antibodies in vaccinated dogs, with a 90.48% sensitivity and 80.00% specificity, making it suitable for quick screening and monitoring vaccination efforts.
Article Synopsis
- The study analyzed the whole genomes of 22 strains of non-aureus staphylococci (NASM) linked to bovine mastitis from India, revealing a mean genome size of 2.55 Mbp and a GC content of 32.2%.
- Researchers identified 14 distinct sequence types among the strains, with ST1 and ST6 being specifically tied to mastitis cases, and classified the strains into five major clades based on genetic relationships.
- The study also uncovered 32 antimicrobial resistance genes and 53 virulence-associated genes, indicating possible co-evolution with hosts and suggesting the potential for horizontal gene transfer among these strains.
Background Objectives: Theileriosis is an important tick-bome hemoprotozoan disease of cattle which causes severe economic loss due to morbidity and mortality. A diagnostic test having high sensitivity, specificity and easy application at the field level is the need of the hour. In this regard Loop-mediated isothermal amplification (LAMP) is proven to be a sensitive, easy and time efficient method.
View Article and Find Full Text PDFEstimates of the burden of human rabies deaths and animal bites in India, 2022-23: a community-based cross-sectional survey and probability decision-tree modelling study.
Lancet Infect Dis
September 2024
Article Synopsis
- - The study investigates the prevalence of dog bites and human rabies deaths in India, where a significant portion of global rabies cases occurs, aiming to assess progress toward a 2030 elimination goal.
- - A nationwide survey found that in a year, there were approximately 9.1 million dog bites in India, with 20.5% of those bitten not receiving necessary anti-rabies vaccinations (ARV).
- - The study estimates around 5,726 human rabies deaths annually, indicating that, despite some progress, there's still a critical need for improved vaccination and prevention strategies.