Publications by authors named "S Ishikura"
Purpose: To report final results of a prospective study of stereotactic body radiation therapy (SBRT) in patients with previously untreated solitary primary hepatocellular carcinoma (HCC).
Methods And Materials: This prospective, single-arm, multicenter phase 2 trial recruited patients with HCC who were unsuitable for, or refused, surgery and radiofrequency ablation, with 3-year overall survival rates as the primary endpoint and survival outcomes and adverse events as secondary endpoints. The prescribed SBRT dose was 40 Gy in 5 fractions.
Article Synopsis
- * RAD52, an SSA factor, is more often pulled to repair DSBs at centromeres compared to RAD51 (HR) and DNA ligase IV (NHEJ), suggesting that SSA is key in repairing these breaks, especially at inactive centromeres.
- * Depleting LIG4 or RAD51 increases cell death after DSBs occur at centromeres, while reducing RAD52 prevents this
Article Synopsis
- Hypothyroidism is a common late side effect following radiotherapy for head and neck cancer, which the JCOG1008 trial aimed to investigate by analyzing patient data.
- The trial enrolled 261 patients from 28 institutions between 2012 and 2018 and conducted thyroid function tests to identify factors associated with developing hypothyroidism post-treatment.
- Results showed that 16.7% of patients developed hypothyroidism within 2 years, with significant factors being the use of weekly cisplatin and lower baseline free thyroxine levels in those undergoing intensity-modulated radiotherapy.
Background/aim: In a previous study, we have demonstrated heightened Pyra-Metho-Carnil (PMC) efficacy in nude mice with intact innate immunity that lack T and B cells. This has prompted hypothesizing that PMC may target macrophages that promote cancer growth. In this study, we conducted co-culture experiments with macrophages derived from THP-1 human monocyte cell lines and spheroids representing normal and cancer microenvironments.
View Article and Find Full Text PDFThis study investigated the appropriate dose prescription method in static multi-beam stereotactic body radiotherapy for lung tumors. Static multi-beam stereotactic body radiotherapy is a mainstream treatment in Japan. Based on the hypothesis that dose prescription to lower isodose lines may improve planning target volume dose coverage and decrease doses to organs at risk, we investigated changes in dose-volume histograms with prescription to various isodose lines for planning target volume in static multi-beam stereotactic body radiotherapy.
View Article and Find Full Text PDF