Publications by authors named "S Ishiguro"
Membrane proteins targeted to the plasma membrane are first transported from the endoplasmic reticulum (ER) to the Golgi apparatus. This study explored the mechanisms controlling plasma membrane trafficking of the boric acid channel AtNIP5;1 from the ER. Imaging-based screening using transgenic Arabidopsis identified six mutants in which GFP-NIP5;1 was localized in the ER in addition to the plasma membrane.
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- In familial adenomatous polyposis (FAP) patients, fundic gland polyps (FGPs) are thought to increase the risk of gastric neoplasms, and this study explored how the distribution of these polyps relates to cancer development.
- A review of 195 FAP patients showed that those with a wider distribution of FGPs (classified from P0 to P4) had a higher likelihood of developing gastric neoplasms, particularly in those who were Helicobacter pylori-negative.
- The study concluded that the pattern of FGP distribution is significantly linked to gastric neoplasm risk in FAP patients, with the most severe distribution (P4) indicating the highest risk.
Article Synopsis
- Familial adenomatous polyposis (FAP) is a hereditary condition leading to hundreds or thousands of colorectal polyps, which can progress to cancer if untreated; it’s caused by mutations in the APC gene.
- The report discusses two cases where women with FAP experienced an increase in fundic gland polyps after using proton pump inhibitors, which were then reduced upon switching medications.
- The study concludes that these types of medications can raise gastrin levels, leading to a rapid increase in polyps, and highlights the need for careful prescription of these drugs in FAP patients.
Working memory (WM) plays a crucial role in various cognitive tasks from language comprehension to problem-solving. However, its influence on social activities has remained largely unexplored. The current two studies on individual differences, a pilot (N = 329) and a pre-registered direct replication (N = 338) study, investigated the relationship between WM and outside-the-lab social interaction by using a listening span task and three social network questionnaires (e.
View Article and Find Full Text PDFThe RNA-guided DNA endonuclease Cas9 cleaves double-stranded DNA targets complementary to an RNA guide, and is widely used as a powerful genome-editing tool. Here, we report the crystal structure of Brevibacillus laterosporus Cas9 (BlCas9, also known as BlatCas9), in complex with a guide RNA and its target DNA at 2.4-Å resolution.
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