Publications by authors named "S Ishigaki"
Objectives: Human T follicular helper (Tfh) cells are classified into three subsets: Tfh1, Tfh2, and Tfh17 cells. Among them,Tfh2 cells are defined as CXCR3-negative and CCR6-negative, and may contain diverse cell populations. We examined whether CCR4 serves as a marker for identifying Tfh2 cells that produce interleukin (IL)-4 and its involvement in IgG4-related disease (IgG4-RD).
View Article and Find Full Text PDFWe explored effective therapeutic targets for systemic sclerosis (SSc) patients with high risk for pulmonary arterial hypertension (PAH) by plasma proteomics analysis. A total of fifty-seven patients with SSc were enrolled in the study and the prevalence of PAH was 19.3%.
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- Interleukin-1 is a key pro-inflammatory cytokine linked to the development of inflammatory diseases, where its absence in knockout mice leads to conditions like aortitis, arthritis, and dermatitis.
- Research shows that transferring T cells from these IL-1Ra KO mice into nude mice causes similar inflammatory diseases, raising questions about which specific T cell subsets are involved.
- The study found increased levels of a particular CD4+ T cell subset that produces granulocyte macrophage colony-stimulating factor (GM-CSF) in IL-1Ra KO mice, suggesting these cells play a significant role in the enhanced inflammation observed in these models.
Article Synopsis
- The study aimed to investigate the differences in cytotoxic CX3CR1+ T cell subsets between two types of large vessel vasculitis: giant cell arteritis (GCA) and Takayasu's arteritis (TAK).
- Scientists analyzed blood samples from 30 patients (22 with GCA and 8 with TAK) and 16 healthy individuals to compare the proportion of CX3CR1+ CD4+ and CD8+ T cells, as well as their presence in inflamed arteries.
- The results reveal a significant increase in CX3CR1+ CD4+ T cells in GCA, associated with inflammation severity, while no such correlation was found in TAK, suggesting that these cells play a crucial role
Article Synopsis
- Researchers created a new method that uses light to break down digermanes by oxidizing them with a photocatalyst, which produces germyl radicals.
- This innovative technique enables the addition of trimethylgermyl groups and deuterium to alkenes, making it a breakthrough in organic synthesis.
- The method is valuable in medicinal chemistry because it allows for the use of stable alternatives to common groups like -butyl and hydrogen in drug design.