Publications by authors named "S Irtan"
Background And Aims: Image Defined Risk Factors (IDRFs) assess surgical risk in neuroblastoma (NB) and guide neoadjuvant therapy. Despite chemotherapy IDRFs may persist in 70 % of cases. Several studies have suggested that not all IDRFs hold equal significance and that the presence of an IDRF does not inherently signify unresectability.
View Article and Find Full Text PDFGrowth velocity of fetal sacrococcygeal teratoma as predictor of perinatal morbidity and mortality: multicenter study.
Ultrasound Obstet Gynecol
November 2024
Objective: To identify prenatal predictors of poor perinatal outcome in fetuses with isolated sacrococcygeal teratoma (SCT).
Methods: This was a retrospective study of fetuses with isolated (non-syndromic) SCT managed at one of five pediatric surgery and/or fetal medicine centers between January 2007 and December 2017. The primary outcome was the occurrence of poor perinatal outcome, defined as prenatal death (including termination), or neonatal death or severe compromise (hemorrhagic shock).
Introduction: Total nephrectomies for the treatment of Wilms' tumor (WT) are more and more performed by laparoscopy, although indications for this approach following the UMBRELLA guidelines are currently very restrictive. The purpose of this study was to assess the compliance to the criteria of the UMBRELLA protocol for minimally invasive approach of WT.
Methods: This retrospective multicenter study included children operated on by laparoscopic total nephrectomy for suspected WT before 2020.
Childhood pancreatic neuroendocrine neoplasms: A national experience.
Pediatr Blood Cancer
February 2025
Article Synopsis
- Pancreatic neuroendocrine neoplasms (pNENs) are rare in children, with a study examining cases between 2011 and 2020 to understand their clinical presentation and behavior.
- The study analyzed 15 patients, mostly adolescents, and found that a significant number had cancer predisposition syndromes, with some diagnosed through screening.
- Results showed that patients with low-grade tumors had better survival rates, while those with high-grade or metastatic cancers faced poorer outcomes, highlighting the need for improved treatment strategies for severe cases.
Multimodality detection of tumour rupture in children with Wilms tumour.
Pediatr Blood Cancer
November 2024
Background And Aims: Tumour rupture (TR) signifies stage III disease and requires treatment intensification, which includes radiotherapy. We studied the associations between radiological, surgical and pathology TR in children with Wilms tumour (WT) in a United Kingdom multicentre clinical study.
Patients And Methods: The IMPORT (Improving Population Outcomes for Renal Tumours of Childhood) study registered 712 patients between 2012 and 2021.