Publications by authors named "S Ingvast"
Aims/hypothesis: Defensins play a crucial role in the innate immune system's first defense against microbial threats. However, little is known about the defensin system in the pancreas, especially in relation to Type 1 diabetes. We explore the expression of defensins in different disease stages of Type 1 diabetes and correlated obtained findings to the degree of inflammation, providing new insights into the disease and the innate immune system.
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- Rheumatoid arthritis (RA) is a significant inflammatory joint disease, and identifying it early is crucial for management, with CD69 serving as an early marker of immune cell activation found in affected tissues.
- A study utilized a CD69-targeting PET agent, [Ga]Ga-DOTA-Z, to detect RA in a mouse model by monitoring disease progression through imaging and clinical symptoms like body weight and paw swelling.
- Findings revealed that [Ga]Ga-DOTA-Z uptake increased before clinical symptoms appeared, correlating with disease severity and confirming CD69 presence in tissues, suggesting it may help in early RA diagnosis.
Article Synopsis
- PDGFRβ is often overexpressed in activated hepatic stellate cells, making it a target for imaging liver fibrosis using PET scans.
- The fluorine-18 radiolabeled Affibody molecule ([F]TZ-Z09591) shows strong binding affinity to PDGFRβ and demonstrates rapid clearance in healthy subjects with minimal liver background.
- Findings indicate that [F]TZ-Z09591 effectively targets fibrotic livers, allowing for the quantification of fibrogenesis and correlating well with existing histopathological assessments.
Today, there is a lack of clinically available imaging techniques to detect and quantify specific immune cell populations. Neutrophils are one of the first immune cells at the site of inflammation, and they secrete the serine protease neutrophil elastase (NE), which is crucial in the fight against pathogens. However, the prolonged lifespan of neutrophils increases the risk that patients will develop severe complications, such as acute respiratory distress syndrome (ARDS).
View Article and Find Full Text PDFPurpose: In the characterization of severe lung diseases, early detection of specific inflammatory cells could help to monitor patients' response to therapy and increase chances of survival. Macrophages contribute to regulating the resolution and termination of inflammation and have increasingly been of interest for targeted therapies. [Ga]Ga-DOTA-TATE is an established clinical radiopharmaceutical targeting somatostatin receptor subtype 2 (SSTR 2).
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