Publications by authors named "S Illi"
Article Synopsis
- - The study investigates how early-life risk factors from both host and environment interact with an infant's respiratory system to influence the development of wheezing and asthma over time.
- - Researchers analyzed data from two large cohorts of healthy infants (BILD and PASTURE) to identify the effects of various factors on wheezing and asthma outcomes, specifically tracking symptom severity scores over the first year of life.
- - Findings showed a complex dynamic interplay between different risk factors and breathing symptoms, ultimately highlighting the importance of these interactions in predicting respiratory health outcomes in young children.
Introduction: Eosinophil-derived neurotoxin (EDN) is a biomarker for eosinophilic activation. Urinary (u) EDN may allow non-invasive monitoring of asthma, but clinical recommendations are lacking. We assessed the potential of uEDN as a marker of disease activity in pediatric asthma.
View Article and Find Full Text PDF17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma.
Am J Respir Crit Care Med
April 2024
The strongest genetic risk factor for childhood-onset asthma, the 17q21 locus, is associated with increased viral susceptibility and disease-promoting processes. To identify biological targets underlying the escalated viral susceptibility associated with the clinical phenotype mediated by the 17q21 locus. Genome-wide transcriptome analysis of nasal brush samples from 261 children (78 healthy, 79 with wheezing at preschool age, 104 asthmatic) within the ALLIANCE (All-Age-Asthma) cohort, with a median age of 10.
View Article and Find Full Text PDFContinuous Rather Than Solely Early Farm Exposure Protects From Hay Fever Development.
J Allergy Clin Immunol Pract
February 2023
Background: An important window of opportunity for early-life exposures has been proposed for the development of atopic eczema and asthma.
Objective: However, it is unknown whether hay fever with a peak incidence around late school age to adolescence is similarly determined very early in life.
Methods: In the Protection against Allergy-Study in Rural Environments (PASTURE) birth cohort potentially relevant exposures such as farm milk consumption and exposure to animal sheds were assessed at multiple time points from infancy to age 10.
Background: Comprehensive studies investigated the role of T-cells in asthma which led to personalised treatment options targeting severe eosinophilic asthma. However, little is known about the contribution of B-cells to this chronic inflammatory disease. In this study we investigated the contribution of various B-cell populations to specific clinical features in asthma.
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