Publications by authors named "S Iliadis"
Breast and endometrial safety of micronised progesterone versus norethisterone acetate in menopausal hormone therapy (PROBES): study protocol of a double-blind randomised controlled trial.
BMJ Open
October 2024
Article Synopsis
- - The Progesterone Breast Endometrial Safety Study aims to compare the safety of micronised progesterone (mP) to synthetic progestins (norethisterone acetate) in hormone therapy for menopausal women, focusing on breast and endometrial health.
- - Conducted at three university hospitals in Sweden, the study consists of two parts: the first assesses breast safety in a double-blind trial with 260 women, while the second evaluates endometrial safety with an additional 260 women using mP.
- - The research has ethical approval and results will be shared in scientific publications and meetings, with a total of 520 participants in both phases combined.
Article Synopsis
- The study investigates the link between telomere length (TL) and peripartum depression (PPD), examining how adverse childhood experiences (ACE) and genetic variations affect this relationship.
- Results indicate that shorter TL is associated with more severe PPD symptoms, particularly at pregnancy week 32 and six weeks postpartum, highlighting a potential biological marker for understanding PPD.
- ACE plays a significant role in moderating the TL-PPD connection, with individuals experiencing greater ACE showing a more pronounced shortening of TL in persistent PPD cases compared to healthy controls.
Reactive oxygen species (ROS) are produced during cellular metabolism and in response to environmental stress. While low levels of ROS play essential physiological roles, excess ROS can damage cellular components, leading to cell death or transformation. ROS can also regulate protein interactions in cancer cells, thereby affecting processes such as cell growth, migration, and angiogenesis.
View Article and Find Full Text PDFBackground: We examined differences in DNA methylation patterns in the and genes in relation to personality vulnerability to depression, resilience, and perinatal depressive symptoms, whilst also considering possible moderating effects of childhood traumatic events.
Methods: = 160 perinatal women were assessed at late pregnancy and 1 year postpartum for personality vulnerability to depression, resilience, depressive symptoms, and childhood traumatic events with self-reported questionnaires. and methylation markers were analyzed via sodium bisulfite sequencing.
Background: Perinatal depression affects a significant number of women during pregnancy and after birth, and early identification is imperative for timely interventions and improved prognosis. Mobile apps offer the potential to overcome barriers to health care provision and facilitate clinical research. However, little is known about users' perceptions and acceptability of these apps, particularly digital phenotyping and ecological momentary assessment apps, a relatively novel category of apps and approach to data collection.
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